Abstract
Background: Parathyroid hormone (PTH) regulates the content of calcium and exerts an effect on myocardial function Abnormal secretion of PTH has been reported with depressed mechanical performance of the heart muscle.
Aim is to evaluate parathyroid function in patients with CHF due to dilated cardiomyopathy (DCM), measuring some different parameters of calcium metabolism.
Patients and Methods: A case- control study carried on 30 cases (20 males and 10 females) with congestive heart failure (CHF) having a mean age of 66 9±394 years They were recruited from Cardiomyopathy Clinic in Children Hospital Cairo University Cases were further classified into(i) Decompensated HF(n=18) (NYHA III, IV) (ii) Compensated HF(n=12) (NYHA II) Thirty healthy children (matched age and sex) were enrolled to serve as control Parathyroid hormone (PTH) and Osteocalcin (OC) were measured, in addition to total serum calcium, phosphorus, alkaline phosphatase, sodium and potassium.
Results: There is statistically significant lower serum calcium, osteocalcin and higher serum phosphorus levels in DCM cases compared to controls (P=00001, 00001,0002 respectively) There was no statistically significant difference between cases and controls regarding serum PTH ie normal PTH despite depressed calcium in DCM
Conclusion: Although three decompenstated CHF cases showed elevated Parathyroid hormone levels, (NS) PTH levels were normal inrest of cases. Significant hypocalcemia, hyperphosphatemia and reduction in serum Osteocalcin levels were noted in CHF patients Whether, or not, these factors contribute to systemic illness that accompanies CHF, including bone wasting, mandates further probing
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Fattouh, A., Said, R., El Din, N. et al. 649 Parathyroid Hormone (PTH) and Markers of Calcium Metabolism in Children with Congestive Heart Failure. Pediatr Res 68 (Suppl 1), 332 (2010). https://doi.org/10.1203/00006450-201011001-00649
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DOI: https://doi.org/10.1203/00006450-201011001-00649
