Abstract
Impaired cerebral oxygen delivery may cause cerebral damage in preterm infants. At lower levels of cerebral perfusion and oxygen concentration, electrocerebral activity is disturbed. The balance between cerebral oxygen delivery and oxygen use can be measured by near-infrared spectroscopy (NIRS), and electrocerebral activity can be measured by amplitude-integrated EEG (aEEG). Our aim was to determine the relationship between regional cerebral tissue oxygen saturation (rcSO2), fractional tissue oxygen extraction (FTOE), and aEEG. We recorded longitudinal digital aEEG and rcSO2 prospectively in 46 preterm infants (mean GA 29.5 wk, SD 1.7) for 2 hr on the 1st to 5th, 8th, and 15th d after birth. We excluded infants with germinal matrix hemorrhage exceeding grade I and recordings of infants receiving inotropes. FTOE was calculated using transcutaneous arterial oxygen saturation (tcSaO2) and rcSO2 values: (tcSaO2 − rcSO2)/tcSaO2. aEEG was assessed by calculating the mean values of the 5th, 50th, and 95th centiles of the aEEG amplitudes. The aEEG amplitude centiles changed with increasing GA. FTOE and aEEG amplitude centiles increased significantly with postnatal age. More mature electrocerebral activity was accompanied by increased FTOE. FTOE also increased with increasing postnatal age and decreasing Hb levels.
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Abbreviations
- aEEG:
-
amplitude-integrated EEG
- BS:
-
burst suppression
- CNV:
-
continuous normal voltage
- CPAP:
-
continuous positive airway pressure
- DNV:
-
discontinuous normal voltage
- FTOE:
-
fractional tissue oxygen extraction
- IVH:
-
intraventricular hemorrhage
- NIRS:
-
near-infrared spectroscopy
- Paco2:
-
arterial partial pressure of carbon dioxide
- PDA:
-
persistent ductus ateriosus
- PVL:
-
periventricular leukomalacia
- rcSO2:
-
regional cerebral oxygen saturation
- SWC:
-
sleep-wake cycling
- tcSao2:
-
transcutaneous arterial oxygen saturation
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Acknowledgements
This study was part of the research program of the Research School for Behavioral and Cognitive Neurosciences, University of Groningen, The Netherlands. We are grateful to K. van Braeckel for statistical advice and we thank Dr. Titia Brantsma-van Wulfften Palthe in Utrecht for correcting the English.
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ter Horst, H., Verhagen, E., Keating, P. et al. The Relationship Between Electrocerebral Activity and Cerebral Fractional Tissue Oxygen Extraction in Preterm Infants. Pediatr Res 70, 384–388 (2011). https://doi.org/10.1203/PDR.0b013e3182294735
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DOI: https://doi.org/10.1203/PDR.0b013e3182294735
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