Abstract
Introduction:
This study aimed to examine the association between cannabis use before and during pregnancy and birth outcomes.
Results:
Overall, 26.3% of women reported previous use of cannabis and 2.6% reported current use. Multivariate analysis, controlling for potential confounders, including tobacco smoking, alcohol consumption, and use of other illicit drugs, showed that cannabis use in pregnancy was associated with low birth weight (odds ratio (OR) = 1.7; 95% confidence interval (CI): 1.3–2.2), preterm labor (OR = 1.5; 95% CI: 1.1–1.9), small for gestational age (OR = 2.2; 95% CI: 1.8–2.7), and admission to the neonatal intensive care unit (OR = 2.0; 95% CI: 1.7–2.4).
Discussion:
The results of this study show that the use of cannabis in pregnancy is associated with increased risk of adverse birth outcomes. Prevention programs that address cannabis use during pregnancy are needed.
Methods:
Data were from women birthing at the Mater Mothers’ Hospital in Brisbane, Australia, over a 7-y period (2000–2006). Women were interviewed in the initial antenatal visit about their use of cannabis and other substances. Records for 24,874 women who provided information about cannabis use, and for whom birth outcomes data were available, were included in the analysis.
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References
Richardson R, Bolisetty S, Ingall C . The profile of substance-using pregnant mothers and their newborns at a regional rural hospital in New South Wales. Aust N Z J Obstet Gynaecol 2001;41:415–9.
Substance Abuse and Mental Health Services Administration. Results From the 2007 National Survey on Drug Use and Health: National Findings (NSDUH Series H-34, DHHS Publication No. SMA 08-4343). Rockville, MD: Department of Health and Human Services, 2008.
Australian Institute of Health and Welfare. National Drug Strategy Household Survey: First Results. Canberra: AIHW2008, 2007.
Zuckerman B, Frank DA, Hingson R, et al. Effects of maternal marijuana and cocaine use on fetal growth. N Engl J Med 1989;320:762–8.
Bell GL, Lau K . Perinatal and neonatal issues of substance abuse. Pediatr Clin North Am 1995;42:261–81.
Hingson R, Alpert JJ, Day N, et al. Effects of maternal drinking and marijuana use on fetal growth and development. Pediatrics 1982;70:539–46.
Hatch EE, Bracken MB . Effect of marijuana use in pregnancy on fetal growth. Am J Epidemiol 1986;124:986–93.
Sherwood RA, Keating J, Kavvadia V, Greenough A, Peters TJ . Substance misuse in early pregnancy and relationship to fetal outcome. Eur J Pediatr 1999;158:488–92.
Kline J, Stein Z, Hutzler M . Cigarettes, alcohol and marijuana: varying associations with birthweight. Int J Epidemiol 1987;16:44–51.
Gibson GT, Baghurst PA, Colley DP . Maternal alcohol, tobacco and cannabis consumption and the outcome of pregnancy. Aust N Z J Obstet Gynaecol 1983;23:15–9.
Tennes K, Avitable N, Blackard C, et al. Marijuana: prenatal and postnatal exposure in human. In: Pinkert TM, ed. NIDA Research Monograph 59. Rockville, MD: National Institute on Drug Abuse, 1985:48–62.
Day N, Sambamoorthi U, Taylor P, et al. Prenatal marijuana use and neonatal outcome. Neurotoxicol Teratol 1991;13:329–34.
Lang JM, Lieberman E, Cohen A . A comparison of risk factors for preterm labor and term small-for-gestational-age birth. Epidemiology 1996;7:369–76.
Linn S, Schoenbaum SC, Monson RR, Rosner R, Stubblefield PC, Ryan KJ . The association of marijuana use with outcome of pregnancy. Am J Public Health 1983;73:1161–4.
Fergusson DM, Horwood LJ, Northstone K . Maternal use of cannabis and pregnancy outcome. BJOG 2002;109:21–7.
Shiono PH, Klebanoff MA, Nugent RP, et al. The impact of cocaine and marijuana use on low birth weight and preterm birth: a multicenter study. Am J Obstet Gynecol 1995;172(1 Pt 1):19–27.
Fried PA, O’Connell CM . A comparison of the effects of prenatal exposure to tobacco, alcohol, cannabis and caffeine on birth size and subsequent growth. Neurotoxicol Teratol 1987;9:79–85.
Witter FR, Niebyl JR . Marijuana use in pregnancy and pregnancy outcome. Am J Perinatol 1990;7:36–8.
Day NL, Richardson GA . Prenatal marijuana use: epidemiology, methodologic issues, and infant outcome. Clin Perinatol 1991;18:77–91.
Pegues DA, Engelgau MM, Woernle CH . Prevalence of illicit drugs detected in the urine of women of childbearing age in Alabama public health clinics. Public Health Rep 1994;109:530–8.
Lester BM, ElSohly M, Wright LL, et al. The Maternal Lifestyle Study: drug use by meconium toxicology and maternal self-report. Pediatrics 2001;107:309–17.
Hingson R, Zuckerman B, Amaro H, et al. Maternal marijuana use and neonatal outcome: uncertainty posed by self-reports. Am J Public Health 1986;76:667–9.
Koren G, Chan D, Klein J, Karaskov T . Estimation of fetal exposure to drugs of abuse, environmental tobacco smoke, and ethanol. Ther Drug Monit 2002;24:23–5.
Chiang C, Hawks R . Implications of drug levels in body fluids: basic concepts. NIDA Research Monograph Series No 79. Rockville, MD: National Institute on Drug Abuse, 1986.
Pain S, Chang AM, Flenady V, Chan FY . Customised birthweight: coefficients for an Australian population and validation of the model. Aust N Z J Obstet Gynaecol 2006;46:388–94.
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Hayatbakhsh, M., Flenady, V., Gibbons, K. et al. Birth outcomes associated with cannabis use before and during pregnancy. Pediatr Res 71, 215–219 (2012). https://doi.org/10.1038/pr.2011.25
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DOI: https://doi.org/10.1038/pr.2011.25
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