Abstract
Aim: To determine the association between hyperglycaemia (HG) in the first two weeks of life and retinopathy of prematurity (ROP) in preterm infants.
Method: Retrospective case control study of infants born at ≤31 weeks of gestation and/or birth weight ≤1500 g over three years. Data collected: demographic, CRIB score, blood sugars, age birth weight (BW) regained, culture proven sepsis, ROP, FiO2 and pCO2 measurements during first two weeks of life. Infants who died before ROP screening, major congenital anomalies and ex-utero transfers after 24 hours of age were excluded.
Results: Out of 312 eligible infants 57 infants excluded because ROP result was not obtainable from their local hospitals. The mean BW (888 g in ROP v 1175 g in control, p< 0.001) & gestational age (26.4 weeks v 29, p< 0.001) was significantly lower, and CRIB scores (10.3 v 6.9, p < 0.001) higher in ROP infants. Significantly higher number of infants with HG (80.4% v 29.4%, p < 0.001) and sepsis (84.6% v 28.9%, p < 0.001) developed ROP. There was no significant association with the other factors studied and ROP.
Conclusion: HG and sepsis are strongly associated with ROP along with well established other (GA, BW) risk factors.
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Mannan, K., Winson, E., Adams, G. et al. Is Hyperglycaemia Associated with Retinopathy of Prematurity?. Pediatr Res 70 (Suppl 5), 675 (2011). https://doi.org/10.1038/pr.2011.900
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DOI: https://doi.org/10.1038/pr.2011.900
