Abstract
Background:
Growing evidence has revealed a link between autoimmune and allergic diseases. However, few studies have assessed the relationship between allergic diseases and primary immune thrombocytopenia (ITP), an autoimmune disease frequently occurring in children. This population-based case–control study investigated the association between common allergic diseases and the subsequent risk of developing ITP during childhood.
Methods:
This study investigated 1,203 children younger than 18 y of age who were diagnosed with ITP between 1998 and 2008, as well as 4,812 frequency-matched controls. The odds ratios of the association between ITP and preexisting allergic diseases were calculated.
Results:
Children with every type of allergic disease examined in this study (except asthma) exhibited an increased risk of developing ITP; the lowest adjusted odds ratio (aOR) was 1.39 for allergic conjunctivitis (95% confidence interval (CI) = 1.09–1.79), whereas the greatest aOR was 1.84 for allergic rhinitis (95% CI = 1.49–2.27). The aORs increased with the number of concurrent allergic diseases to 2.89 (95% CI = 1.98–4.22) for children with at least three allergic diseases.
Conclusion:
Children with atopic diathesis have a greater risk of subsequently developing ITP. The fundamental determinants of this relationship warrant further study.
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Acknowledgements
Ming-Ru Chiang and Chang-Ching Wei contributed equally to the conceptualization and design of the study, as well as drafting and approving the final version of the manuscript. Chin-Shin Muo, Lin-Shien Fu, and Tsai-Chung Li conducted the initial analysis, reviewed and revised the manuscript, and approved the final manuscript. Chia-Hung Kao coordinated and supervised the data collection process and critically reviewed the manuscript, and approved the final manuscript.
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Chiang, MR., Wei, CC., Muo, CS. et al. Association of primary immune thrombocytopenia and common allergic diseases among children. Pediatr Res 77, 597–601 (2015). https://doi.org/10.1038/pr.2015.6
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DOI: https://doi.org/10.1038/pr.2015.6
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