Abstract
Background:
Although clinical and immunological studies have shown a possible link between allergy and idiopathic nephrotic syndrome (INS), the nature of the relationship remains unclear. Asthma is the most common chronic allergic airway inflammation. However, no study has used a longitudinal design with a population cohort to investigate INS in children with asthma.
Methods:
Using nationwide claims data from 2000 through 2007, we randomly selected 251,698 asthma cases and 1,006,791 frequency-matched controls. Incidence rates of INS and hazard ratios (HRs) were calculated.
Results:
The INS incidence was 3.36-fold greater in the asthma cohort than in the nonasthma control (9.26 vs. 2.76 per 100,000 person-years; 95% confidence interval (CI): 2.65–4.26). The HR for INS increased for those with more asthma-related medical visits per year, from 1.49 (95% CI: 1.06–2.11) for <3 visits to 15.7 (95% CI: 11.5–21.5) for ≥6 visits (trend test, P < 0.0001). The HR for INS slightly decreased during the follow-up period, from 3.41 (95% CI: 2.66–4.38) for ≤5.5 y to 2.90 (95% CI: 1.33–6.30) for >5.5 y.
Conclusion:
We conclude that children with asthma had an increased incidence rate of INS, and increased incidence rate correlated with asthma-related medical visits.
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Acknowledgements
C.-C.W. and T.-C.S. conceptualized and designed the study, drafted the manuscript, and approved the final manuscript as submitted. C.-L.L. conducted the initial analyses, reviewed and revised the manuscript, and approved the final manuscript as submitted. C.-C.W. and Y.-F.L. coordinated and supervised the data collection, critically reviewed the manuscript, and approved the final manuscript as submitted.
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Wei, CC., Lin, CL., Shen, TC. et al. Risk of idiopathic nephrotic syndrome among children with asthma: a nationwide, population-based cohort study. Pediatr Res 78, 212–217 (2015). https://doi.org/10.1038/pr.2015.80
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DOI: https://doi.org/10.1038/pr.2015.80
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