Abstract
Background:
Bronchopulmonary dysplasia (BPD) portends lifelong organ impairment and death. Our ability to predict BPD in first days of life is limited, but could be enhanced using novel biomarkers.
Methods:
Using an available clinical and urine biomarker database obtained from a prospective 113 infant cohort (birth weight ≤1,200 g and/or gestational age ≤31 wk), we evaluated the independent association of 14 urine biomarkers with BPD/mortality.
Results:
Two of the 14 urine biomarkers were independently associated with BPD/mortality after controlling for gestational age (GA), small for gestational age (SGA), and intubation status. The best performing protein was clusterin, a ubiquitously expressed protein and potential sensor of oxidative stress associated with lung function in asthma patients. When modeling for BPD/mortality, the independent odds ratio for maximum adjusted urine clusterin was 9.2 (95% CI: 3.3–32.8, P < 0.0001). In this model, clinical variables (GA, intubation status, and SGA) explained 38.3% of variance; clusterin explained an additional 9.2%, while albumin explained an additional 3.4%. The area under the curve incorporating clinical factors and biomarkers was 0.941.
Conclusion:
Urine clusterin and albumin may improve our ability to predict BPD/mortality. Future studies are needed to validate these findings and determine their clinical usefulness.
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Acknowledgements
The authors wish to thank Emma Perez-Costas, PhD (Department of Pediatrics, University of Alabama at Birmingham) who performed substantive science editing as well as proofreading of this manuscript.
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Balena-Borneman, J., Ambalavanan, N., Tiwari, H. et al. Biomarkers associated with bronchopulmonary dysplasia/mortality in premature infants. Pediatr Res 81, 519–525 (2017). https://doi.org/10.1038/pr.2016.259
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DOI: https://doi.org/10.1038/pr.2016.259
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