Abstract
Background:
Concerns have been raised that with an increase in the number of vaccines administered early in life, immune development could be altered, leading to either increased or decreased immune reactivity.
Methods:
We investigated the impact of vaccination on immune status, contrasting the immune response to general, nonantigen-specific stimuli in a cohort of entirely unvaccinated vs. fully vaccinated children at 3–5 y of age. Innate immunity was assessed by quantifying bulk and cell-type-specific cytokine production in response to stimulation with pathogen associated microbial patterns. Adaptive immune status was characterized by assessing lymphocyte proliferation and cytokine production in response to generic T cell stimuli.
Results:
Our investigations failed to reveal a broadly evident alteration of either innate or adaptive immunity in vaccinated children. Equivalently robust innate and adaptive responses to pathogen associated microbial patterns and generic T cell stimulants were observed in both groups.
Conclusion:
Although our sample size was small, our data suggest that standard childhood vaccinations do not lead to long-lasting gross alterations of the immune system.
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References
Clemens J, Holmgren J, Kaufmann SH, Mantovani A. Ten years of the Global Alliance for Vaccines and Immunization: challenges and progress. Nat Immunol 2010;11:1069–72.
Hostetter MK. What we don’t see. N Engl J Med 2012;366:1328–34.
Larson HJ, Cooper LZ, Eskola J, Katz SL, Ratzan S. Addressing the vaccine confidence gap. Lancet 2011;378:526–35.
Offit PA, Quarles J, Gerber MA, et al. Addressing parents’ concerns: do multiple vaccines overwhelm or weaken the infant’s immune system? Pediatrics 2002;109:124–9.
Hilton S, Petticrew M, Hunt K. ‘Combined vaccines are like a sudden onslaught to the body’s immune system’: parental concerns about vaccine ‘overload’ and ‘immune-vulnerability’. Vaccine 2006;24:4321–7.
Corbett NP, Blimkie D, Ho KC, et al. Ontogeny of toll-like receptor mediated cytokine responses of human blood mononuclear cells. PLoS One 2010;5:e15041.
Reikie BA, Adams RC, Ruck CE, et al. Ontogeny of toll-like receptor mediated cytokine responses of South African infants throughout the first year of life. PLoS One 2012;7:e44763.
Smolen KK, Ruck CE, Fortuno ES 3rd, et al. Pattern recognition receptor-mediated cytokine response in infants across 4 continents. J Allergy Clin Immunol 2014;133:818–26.e4.
Blimkie D, Fortuno ES 3rd, Yan H, et al. Variables to be controlled in the assessment of blood innate immune responses to toll-like receptor stimulation. J Immunol Methods 2011;366:89–99.
Jansen K, Blimkie D, Furlong J, et al. Polychromatic flow cytometric high-throughput assay to analyze the innate immune response to toll-like receptor stimulation. J Immunol Methods 2008;336:183–92.
Kollmann TR, Crabtree J, Rein-Weston A, et al. Neonatal innate TLR-mediated responses are distinct from those of adults. J Immunol 2009;183:7150–60.
Soares A, Govender L, Hughes J, et al. Novel application of Ki67 to quantify antigen-specific in vitro lymphoproliferation. J Immunol Methods 2010;362:43–50.
Offit PA, Hackett CJ. Addressing parents’ concerns: do vaccines cause allergic or autoimmune diseases? Pediatrics 2003;111:653–9.
Labuda LA, de Jong SE, Meurs L, et al. Differences in innate cytokine responses between European and African children. PLoS One 2014;9:e95241.
Andersen A, Jensen KJ, Erikstrup C, et al. Both very low- and very high in vitro cytokine responses were associated with infant death in low-birth-weight children from Guinea Bissau. PLoS One 2014;9:e93562.
Blok BA, Arts RJ, van Crevel R, Benn CS, Netea MG. Trained innate immunity as underlying mechanism for the long-term, nonspecific effects of vaccines. J Leukoc Biol 2015;98:347–56.
Plotkin S. History of vaccination. Proc Natl Acad Sci USA. 2014;111:12283–7.
Omer SB, Salmon DA, Orenstein WA, deHart MP, Halsey N. Vaccine refusal, mandatory immunization, and the risks of vaccine-preventable diseases. N Engl J Med 2009;360:1981–8.
Feikin DR, Lezotte DC, Hamman RF, Salmon DA, Chen RT, Hoffman RE. Individual and community risks of measles and pertussis associated with personal exemptions to immunization. JAMA 2000;284:3145–50.
Acknowledgements
The authors gratefully acknowledge Judy Needham for assistance with study coordination, and David Scheifele for insightful comments on the manuscript.
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Sherrid, A., Ruck, C., Sutherland, D. et al. Lack of broad functional differences in immunity in fully vaccinated vs. unvaccinated children. Pediatr Res 81, 601–608 (2017). https://doi.org/10.1038/pr.2016.272
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DOI: https://doi.org/10.1038/pr.2016.272
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