Figure 3
From: Bacillus Calmette-Guérin vaccination, thymic size, and thymic output in healthy newborns
Plots of the association between T cell subsets, lymphocytes, and thymic index in newborns randomized to BCG or no BCG. (a) The association between the absolute cell count (cells/μl) of recent thymic emigrants (RTEs) and TI at 4 d. The linear regression coefficient for CD4+ RTEs (filled circles) = 523 cells/μl pr. doubling of TI, 95 % CI 281–764, P < 0.001 and for CD8+ RTEs (open circles) = 169, 95% CI 48–290, P = 0.007, n = 112. (b) The association between the absolute cell count (cells/μl) of CD4+ and CD8+ T cells and TI at 4 d. The linear regression coefficient for CD4+ (filled circles) = 849 cells/μl pr. doubling of TI, 95% CI 483–1,215, P < 0.001 and for CD8+ (open circles) = 165, 95% CI 41–290, P = 0.01, n = 112. (c) The association between the absolute cell count (cells/μl) of lymphocytes and TI at 4 d. The linear regression coefficient = 1,340 cells/μl pr. doubling of TI, 95% CI 831–1,849, P < 0.001, n = 112.
