Abstract
Multichannel near-infrared spectroscopy (MNIRS) was used for the functional imaging of the sensorimotor cortex of newborn infants during passive knee and elbow movement under sedated sleep. Contralateral knee and elbow movement caused a marked increase in the concentration of oxyhemoglobin ([oxyHb]) from the baseline values at site within the sensorimotor area in all infants. During ipsilateral knee and elbow movement, [oxyHb] showed smaller changes, equivalent to 64 ± 23 and 66 ± 28% of the changes that occurred with contralateral stimulation, respectively. The mean times corresponding to maximal changes in [oxyHb] were 16.1 ± 3.3 s for contralateral knee movement and 17.9 ± 5.7 s for contralateral elbow movement. No significant difference was noted between the mean latencies showing the maximal changes in [oxyHb] between contralateral and ipsilateral movement. There was a significant difference in the area and degree of response between the contralateral and ipsilateral movement. MNIRS could be a useful tool to understand the pathophysiology of the developing brain and monitor cortical responses in various clinical situations.
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Abbreviations
- deoxyHb:
-
deoxyhemoglobin
- fMRI:
-
functional magnetic resonance imaging
- MNIRS:
-
multichannel near-infrared spectroscopy
- NIRS:
-
near-infrared spectroscopy
- oxyHb:
-
oxyhemoglobin
- totalHb:
-
total hemoglobin
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Supported by grants-in-aid for scientific research (C) no. 20591299, 22591202, 22591201, 22591203, and 17390307 from the Ministry of Education, Culture, Sports, Science and Technology of Japan; Sanju Alumni Research Grant 21-1; and The Mother and Child Health Foundation.
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Kusaka, T., Isobe, K., Miki, T. et al. Functional Lateralization of Sensorimotor Cortex in Infants Measured Using Multichannel Near-Infrared Spectroscopy. Pediatr Res 69, 430–435 (2011). https://doi.org/10.1203/PDR.0b013e3182125cbd
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DOI: https://doi.org/10.1203/PDR.0b013e3182125cbd
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