Table 1 Association analyses of PIEZO1 E756del (rs59446030) with severe malaria in the Ghanaian case-control study

From: Human genetic variant E756del in the ion channel PIEZO1 not associated with protection from severe malaria in a large Ghanaian study

 

SM study groupa ntotal = 4149

 

SM cases n = 2413 (%)

Controls n = 1736 (%)

Odds ratiob, 95% CI, p value

PIEZO1 E756 genotype

WT/WT

1483 (61.5)

1037 (59.8)

Ref

WT/del

699 (29.0)

523 (30.1)

0.91 (0.79–1.05) p = 0.19

del/del

91 (3.8)

85 (4.9)

0.71 (0.52–0.98) p = 0.04

WT/ins

107 (4.4)

70 (4.0)

1.04 (0.75–1.42) p = 0.83

del/ins

25 (1.0)

16 (0.9)

1.17 (0.61–2.24) p = 0.63

ins/ins

8 (0.3)

5 (0.3)

1.26 (0.40–3.94) p = 0.70

Hemoglobin type

HbAA

2128 (88.4)

1,314 (75.8)

Ref

HbAS

34 (1.4)

263 (15.2)

0.08 (0.05–0.12) p < 0.00001

HbAC

239 (9.9)

148 (8.5)

0.34 (0.12–0.99) p = 0.05

HbCC

6 (0.3)

9 (0.5)

0.93 (0.75–1.17) p = 0.55

Median age, months (range)

20 (7–117)

30 (7–116)

 

Sex (female, %)

46.1

47.1

 

Ethnic group, n (%)

Akan

1605 (66.5)

1260 (72.6)

 

Northerner

698 (28.9)

442 (25.4)

 

Ewe

73 (3.1)

24 (1.4)

 

Ga

37 (1.5)

10 (0.6)

 
  1. SM severe malaria, CI confidence interval.
  2. aSevere malaria case group includes discrete and partly overlapping phenotypes, severe malaria anemia defined as hemoglobin level <5 g/dl, cerebral malaria defined as Blantyre coma score <3, and hyperlactatemia; prostration, hyperparasitemia, respiratory distress.
  3. bResults of logistic regression adjusted for age, sex and ethnic group.
Back to article page