Fig. 4
Heterozygous deletion of Ubap1 results in axonopathy of the central nervous system. A Semithin sections of the corticospinal tract in the spinal cords of 7-months-old mice at the lumbar level. Scale bar, 20 μm. B The sizes of axons were determined and the percentage of each size is shown. C The violin plots show that thick myelinated fibers are selectively lost in Ubap1+/E176Efx23 knock-in mice (n = 216 each; Mann–Whitney U test; ***p < 0.001). D Arrows denote direct evidence of axonal degeneration, which was not observed in the wild-type mice. Scale bar, 20 μm
