Fig. 5 | Journal of Human Genetics

Fig. 5

From: Ubap1 knock-in mice reproduced the phenotype of SPG80

Fig. 5

Mutations in Ubap1 affect the distributions of Rab5 and Rab7. A Confocal images of spinal cord sections from 7-month-old mice stained for Rab5 (green), Rab7 (green), and DAPI (blue). Scale bar, 10 μm. B Nearest neighbor analysis was performed to quantify the distributions of Rab5 and Rab7 puncta, which are shown in the graph (Rab5: n = 13, Rab7: n = 12; Mann–Whitney U test; ***: p < 0.001). C, D Quantification of the number and size of Rab5 and Rab7 positive puncta was performed (Rab5: n = 13, Rab7: n = 12; Mann–Whitney U test; ***: p < 0.001)

Back to article page