Fig. 3: Inhibition of tumor growth by SOCS2 knockdown in p53-null cells.
From: Alterations in the p53-SOCS2 axis contribute to tumor growth in colon cancer
a Immunoblots from the extracts of colon cancer cells transduced with lentiviral particle encoding SOCS2 shRNA. b Colony formation after SOCS2 knockdown in HCT116 cells. Values represent the mean ± SD from three independent experiments. **P < 0.01. c Tumorigenicity after SOCS2 knockdown. Tumor cells transduced with lentiviral particle encoding SOCS2 shRNA were inoculated into right shoulders of mice and compared with inoculation of nontarget tumor cells into left shoulders (n = 10, **P < 0.01). Tumor growth measured at indicated times (lower panel). Values represent the mean ± SD from three independent experiments. **P < 0.01
