Fig. 3: Mutational spectrum of somatic mutations in DGC. | Experimental & Molecular Medicine

Fig. 3: Mutational spectrum of somatic mutations in DGC.

From: Identification of genomic aberrations associated with lymph node metastasis in diffuse-type gastric cancer

Fig. 3

a, e Venn-diagram showing the number of mutated genes that were overlapped among the N0 and N3 groups in our DGC cohort (a) and TCGA cohort (e). b, f The distribution of the mutation types according to protein functions (top) and substitution types (bottom) in each of our DGC cohorts (b) and in each TCGA cohort (f) is shown. c, g Distribution of the mutation signatures, based on the published signatures from Sanger COSMIC. The contributions of each mutation signature of N0 and N3 tumors in our DGC cohort (c) and in the TCGA cohort (g) are shown. d, h The distribution of triple nucleotides at the mutation flanking site of N0 and N3 tumors in our DGC cohort (d) and in the TCGA cohort (h) is shown. The represented triplet nucleotides are indicated as arrows

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