Fig. 2: TG2 mediates palmitic acid-dependent increase of cardiomyocyte contractility. | Experimental & Molecular Medicine

Fig. 2: TG2 mediates palmitic acid-dependent increase of cardiomyocyte contractility.

From: S-nitrosylation of transglutaminase 2 impairs fatty acid-stimulated contraction in hypertensive cardiomyocytes

Fig. 2

a Sarcomere length of LV myocytes from rats treated with PA was monitored with a video-sarcomere detection system in the absence or presence of CTM (0.5 mM), an inhibitor of TG2 (left). The difference between diastolic and systolic sarcomere length (Δ sarcomere shortening) was compared (right). b Effect of PA supplementation on sarcomere length in LV myocytes in the absence or presence of L-682.777 (100 μM), an inhibitor of TG2. c Effect of PA supplementation on sarcomere length in LV myocytes from wild-type and TG2-deficient mice. A representative graph is shown. Data represent mean ± S.D. **P < 0.01 compared with control

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