Fig. 5: OMP expression in normal human pituitary and PRL-secreting pituitary adenoma.

a Negative correlation between OMP and PKC-ERK1/2 levels in normal human pituitary (lanes 1–3) and prolactinoma (lanes 4–6) tissues, as determined by western blotting. β-Actin served as a loading control. b Representative images of OMP (green) and PRL (red) immunofluorescence labeling in normal and prolactinoma tissue sections. OMP colocalized with PRL in normal tissues, but was undetectable in prolactinoma. Images were obtained by laser scanning microscopy at 100× magnification