Fig 8: miR-125a-5p regulates downstream molecules of TGF-β1 and IL-6 signaling pathway. | Experimental & Molecular Medicine

Fig 8: miR-125a-5p regulates downstream molecules of TGF-β1 and IL-6 signaling pathway.

From: MiR-125a-5p ameliorates monocrotaline-induced pulmonary arterial hypertension by targeting the TGF-β1 and IL-6/STAT3 signaling pathways

Fig 8

a Western blot analysis of STAT3, Smad2/3, PCNA, Survivin, and Bcl-2 in PASMCs treated as indicated. b Summary of the data shown in a. c RT–qPCR results showing the mRNA levels of STAT3, PCNA, and Bcl-2 in PASMCs treated as indicated, expressed relative to the respective control groups. AGO-NC and ANTA-NC refer to negative controls for the miR-125a-5p agomir and antagomir, respectively. *p < 0.05, **p < 0.01, ***p < 0.001, and ****p < 0.0001

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