Fig. 1: Facilitation of 5-HT2AR-mediated arterial contractions by MK801 and ketamine. | Experimental & Molecular Medicine

Fig. 1: Facilitation of 5-HT2AR-mediated arterial contractions by MK801 and ketamine.

From: Enhancement of 5-HT2A receptor function and blockade of Kv1.5 by MK801 and ketamine: implications for PCP derivative-induced disease models

Fig. 1

a Concentration-response curves (CRCs) of 5-HT-induced rat mesenteric arterial contractions in the absence and presence of MK801. b CRC of MK801-induced rat mesenteric arterial contractions in the presence of a physiological concentration (200 nM) of 5-HT. c CRC of (+) and (−) MK801-induced rat mesenteric arterial contractions in the presence of 200 nM of α-methyl 5-HT, a selective 5-HT2AR agonist. d Membrane potential (Em)-independent CRCs of 5-HT-induced rat mesenteric arterial contractions in the absence and presence of MK801 after pretreatment with 70 mM KCl and nifedipine (1 µM). e Em-independent CRCs of 5-HT-induced rat mesenteric arterial contractions in the absence and presence of ketamine after pretreatment with 70 mM KCl and nifedipine (1 µM). f CRC of MK801-induced rat mesenteric arterial contractions in the absence and presence of high (70 mM) KCl. g CRCs of phenylephrine-induced rat aorta contractions in the absence and presence of MK801. N in parentheses indicates the number of animals examined. *p < 0.05; **p < 0.01; N.S. not significant

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