Fig. 6: Gastrin promotes tumor progression of orthotopic tumors in nude mice. | Experimental & Molecular Medicine

Fig. 6: Gastrin promotes tumor progression of orthotopic tumors in nude mice.

From: Gastrin stimulates pancreatic cancer cell directional migration by activating the Gα12/13–RhoA–ROCK signaling pathway

Fig. 6

PANC-1 cells (1 × 107 cells) were injected into the head/neck region of the nude mouse pancreas. a Mice were divided into six groups and treated according to schedule. b, c Immunoblotting (b) and immunohistochemistry (c) results are indicated for paxillin phosphorylation of orthotopic pancreatic cancer tissues. d–f YM022 and Y-27632 significantly inhibited the growth of the primary pancreatic tumor (d, e) and prevented liver metastasis (f). Data are represented as the mean ± SD, *P < 0.05

Back to article page