Table 1 Biochemical analysis of sera of male and female mice in the single dose toxicity test

From: Therapeutic potential of a phospholipase D1 inhibitory peptide fused with a cell-penetrating peptide as a novel anti-asthmatic drug in a Der f 2-induced airway inflammation model

Test item

Male

Female

Control

Low

Medium

High

Control

Low

Medium

High

0 mg/kg

100 mg/kg

200 mg/kg

500 mg/kg

0 mg/kg

100 mg/kg

200 mg/kg

500 mg/kg

ALB (IU/l)

1.78 ± 0.02

1.80 ± 0.03

1.78 ± 0.06

1.70 ± 0.06

1.32 ± 0.16

1.57 ± 0.23

1.43 ± 0.01

1.35 ± 0.09

ALP (IU/l)

262.00 ± 56.45

221.40 ± 22.83

233.20 ± 24.95

249.50 ± 12.99

229.00 ± 31.95

307.00 ± 43.02

275.00 ± 23.23

258.00 ± 31.65

GGT (IU/l)

0.00 ± 0.00

0.00 ± 0.00

0.00 ± 0.00

0.00 ± 0.00

0.00 ± 0.00

0.00 ± 0.00

0.00 ± 0.00

0.00 ± 0.00

TP (IU/l)

5.38 ± 0.04

5.38 ± 0.09

5.30 ± 0.2

5.00 ± 0.2

4.00 ± 0.49

4.77 ± 0.74

4.25 ± 0.09

3.80 ± 0.30

T-BIL (IU/l)

0.10 ± 0.02

0.09 ± 0.01

0.11 ± 0.02

0.11 ± 0.02

0.01 ± 0.01

0.06 ± 0.06

0.03 ± 0.01

0.01 ± 0.01

  1. Data are expressed as means ± SD (n = 5 per each group). Differences were assessed by one-way ANOVA
  2. ALB albumin, ALP alanine aminotransferase, GGT gamma (γ)-glutamyl transferase, TP total protein, T-BIL total bilirubin