Fig. 1: Structural characteristics of rabbit antibodies.
From: The wide utility of rabbits as models of human diseases
a Crystal structure of rabbit anti-HIV-1 gp120 V3 monoclonal antibody R56 (PDB ID 4JO1)121. R56 is used here as an example of typical rabbit antibodies. Rabbit kappa chain often has a disulfide bond linking its VL and CL1 regions, limiting the flexibility of the Fab elbow. This disulfide bond may contribute to the stability of rabbit antibodies in general. Additionally, non-canonical disulfide bonds are often observed in CDR loops of rabbit antibodies. R56 has two disulfide bonds in its antigen bonding site. b Details of the elbow kappa chain disulfide bond. c Details of the R56 antigen-binding site, with its V3 epitope shown in magenta
