Table 3 Summary of NAA10 mutations in mouse
From: N-α-acetyltransferase 10 (NAA10) in development: the role of NAA10
Organism scientific name | Homolog | Symbol of mutation | Type of mutation | Protein effect/ molecular mechanism | Phenotype | Ref. |
|---|---|---|---|---|---|---|
Mouse Mus musculus | Naa10 | TgNaa10235 | Overexpression of Naa10235; two different founders #10 and #15 were used | Blocks the Runx2–CBFb interaction by acetylating Runx2 at K225 | Delayed calvarial cone development | |
Naa10 KO | Remove Exon1 containing the start codon and Exon2–4 containing N-acetyltransferases, NLS and the Acetyl-coA binding domain | Enhance the the Runx2–CBFb interaction | Facilitating calvarial bone development | |||
Naa10f/Y; EIIa-Cre | Insertion of loxp into the intron 1 and 6, and the Neo cassette flanked by FRT into the sixth intron before loxp; Cre removes exon 2–6 | Disrupts its binding to the imprinted allele at ICRs/DMRs and Dnmt1 recruitment | Partial embryonic lethality, growth retardation, brain disorders, maternal effect lethality, defective genomic imprinting |
