Fig. 2: Comparison of our secretome with the previous secretomes and localization and functional analysis of the secretome.

a Comparison of our secretome with human plasma secretomes previously reported and with protein-coding genes known to be localized in the extracellular region based on their GOCCs. b Comparison of our secretome with two previously reported liver cancer secretomes. c 1766 secreted proteins overlapped with human plasma or liver cancer secretomes. d Distribution of cellular localizations (GOCCs) of the overlapping secreted proteins. Bar colors represent the numbers of secreted proteins localized in the compartments related (blue) or unrelated (green) to secretion. e Cellular processes (GOBPs) represented by the 1766 overlapping secreted proteins. Bar colors indicate a group of the process related to secretion (green) and five groups of the processes related to cancer pathophysiology (blue for cell cycle, orange for immune response, purple for intracellular signaling, brown for protein homeostasis, and gray for metabolism). The dashed line denotes the cutoff of P = 0.01