Fig. 3: Autocrine function of EETs on eosinophil activation.
From: Biological function of eosinophil extracellular traps in patients with severe eosinophilic asthma
a Morphological changes of peripheral blood eosinophils from patients with NSA after 100 nM phorbol myristate acetate (PMA) or 5 µg/mL EET (from NSA) treatment. b Immunofluorescence staining of released EETs (white arrows). Scale bar, 10 µm. c Eosinophil degranulation. d ROS production. e Effect of Dex, HCQ and NAC on eosinophil production of ECP. Data are presented as the mean, n = 5. *P < 0.05, **P < 0.01, and ***P < 0.001 obtained using one-way ANOVA with Bonferroni’s post hoc test. n.s., not significant
