Fig. 6: Effect of the chemical chaperone 4-PBA on the MC4R-mediated regulation of body weight and food intake. | Experimental & Molecular Medicine

Fig. 6: Effect of the chemical chaperone 4-PBA on the MC4R-mediated regulation of body weight and food intake.

From: Glucose-regulated protein 78 binds to and regulates the melanocortin-4 receptor

Fig. 6

a Experimental protocol: 10-week-old male mice were injected with saline or 4-PBA (200 mg/kg, ip) for 5 days; on the 5th day, mice fasted for 16 h were treated with AgRP (2 nmol, i.c.v.) or MTII (3 nmol, i.c.v.). At different time points after each injection, the changes in b body weight and c food intake were measured. Two-way ANOVA, Bonferroni post hoc tests for bc: n = 9 per group, *P < 0.05, **P < 0.01, ***P < 0.001, vehicle versus MTII; ##P < 0.01, ###P < 0.001, vehicle versus AgRP + MTII; P < 0.05, ††P < 0.05, non-4-PBA-treated versus 4-PBA-treated group. The data are presented as the mean ± SEM

Back to article page