Fig. 1: Identification of HS-1371 as a novel RIP3 kinase inhibitor.
From: HS-1371, a novel kinase inhibitor of RIP3-mediated necroptosis

a IC50 curves for RIP3 with HS-1308, 1336, 1338, and 1371 treatments. b Chemical structures of HS-1308, 1336, 1338, and 1371. c, d. c Comparative view of the predicted binding conformations of HS-1308, 1336, 1338 and 1371 in the ATP-binding site of RIP3 (PDB ID: 4M66). Carbon atoms of HS-1308, 1336, 1338 and 1371 are colored in yellow, pink, brown, and green, respectively. d Detailed interaction patterns of HS-1371 in the ATP-binding site of RIP3. Hydrogen-bond interactions are represented with blue dotted lines. e, f. e Michaelis–Menten plot and f Lineweaver-Burk Plot for RIP3 with HS-1371