Fig. 2: Comprehensive profiles of the mitochondrial proteome.

a Comparison of our proteome with two previous mitochondrial proteomes. For the proteins detected in individual studies, the numbers of genes encoding the proteins are shown. Venn diagram showing the relationships of our mitochondrial proteome with the largest previous mitochondrial proteomes. b Relative proportions of cellular components (GOCCs) in which the measured mitochondrial proteins are mainly localized. In each stacked bar, the red bar represents the proportion of proteins that can be localized to mitochondria according to GOCCs (e.g., 40 of 228 plasma membranous proteins can be co-localized to mitochondria). c Distribution of the mitochondrial proteins in sub-mitochondrial localization. d Cellular processes (GOBPs) in which the identified proteins are mainly involved. The bars represent–log₁₀(P), where P represents the significance of each GOBP enriched by the mitochondrial proteins. The P-value was computed using DAVID software. e, f Coverage of the mitochondrial proteome in oxidative phosphorylation complexes. In the stacked bars, the purple bars represent the proportions of proteins detected for all of the proteins included in complex I-V (e) and encoded by the nucleus (Nu-DNA) or mitochondria genome (MT-DNA) (f)