Fig. 8: A schematic of the regulation of the RHOA-ROCK-CFL pathway by CLOCK and BMAL1 in tumor cells.
From: CLOCK and BMAL1 stabilize and activate RHOA to promote F-actin formation in cancer cells
a Analysis of BMAL1, CLOCK, and RHOA in liver cancer (ONCOMINE database). Box plots derived from gene expression data in ONCOMINE in normal and liver cancer tissue. The p value was set up at 0.01, and the fold change was defined as 2; LC liver cancer. b A schematic diagram depicting the regulatory effects of CLOCK and BMAL1 on F-actin/G-actin turnover and its role in cell proliferation, migration, and invasion
