Fig. 6: 6ʹ-SLN treatment attenuates TGF-β1-induced endometriosis in C57BL/6 mice
From: Increased α2-6 sialylation of endometrial cells contributes to the development of endometriosis
a Schematic diagram of the mouse endometriosis model. Endometriosis was induced at day 0. Donor and challenged mice were subjected to ovariectomy at day − 21 and injected subcutaneously with estrogens (100 mg/kg) at days − 7, 0, + 7, + 14, and + 21. Mice challenged with endometrium were inoculated intraperitoneally with 2.5 μg/kg TGF-β1 (0, + 2, + 4 days) and 6ʹ-SLN (daily). At day + 21 after endometriosis induction, challenged mice were killed, and endometriotic lesions were evaluated. b–d Endometriotic lesions were isolated, and the number, volume and weight of foci were calculated
