Fig. 5: PAK4-mediated signaling pathways in melanogenesis.
From: PAK4 signaling in health and disease: defining the PAK4–CREB axis
PAK4 is activated downstream of PKA in the α-MSH signaling pathway and activates the CREB–MITF pathway. PAK4 phosphorylates β-catenin and activates TCF/LEF-dependent transcription, but the Wnt ligands that activate PAK4 remain unclear. PAK4 also functions downstream of Ras, but the exact mechanism is unknown. MITF microphthalmia-associated transcription factor
