Fig. 3: Overexpression of ETV2 significantly improves cardiac function and reduces cardiac fibrosis in a mouse model of myocardial infarction. Mice undergoing MI were injected with lentiviral particles of ETV2-Ires-VENUS or control followed by echocardiography analysis. | Experimental & Molecular Medicine

Fig. 3: Overexpression of ETV2 significantly improves cardiac function and reduces cardiac fibrosis in a mouse model of myocardial infarction. Mice undergoing MI were injected with lentiviral particles of ETV2-Ires-VENUS or control followed by echocardiography analysis.

From: In vivo transduction of ETV2 improves cardiac function and induces vascular regeneration following myocardial infarction

Fig. 3

a, b Ejection fraction (EF) and fractional shortening (FS) were significantly higher in the ETV2-injected group compared to those in control virus-injected group, n = 7–10 for each group. c, d Representative images showing collagen deposition (blue) in the left ventricle of mouse hearts by Masson’s Trichrome staining. Bar graphs summarizing the percentage of fibrosis in the left ventricle of mouse hearts. For each heart, three randomly selected sections from the apex to ligated area were measured, n = 6 for each group. *p < 0.05, **p < 0.01, and ***p < 0.001 compared to control

Back to article page