Fig. 7: Myocardial injection of AAV9-ETV2 improves cardiac function in a rat model of myocardial infarction. | Experimental & Molecular Medicine

Fig. 7: Myocardial injection of AAV9-ETV2 improves cardiac function in a rat model of myocardial infarction.

From: In vivo transduction of ETV2 improves cardiac function and induces vascular regeneration following myocardial infarction

Fig. 7

AAV9-ETV2 and control virus were injected into MI hearts of rats followed by image and functional analysis. a Optical images of sacrificed hearts 8 weeks after injection. White circle shows the area of fibrotic scar formation. b Representative images of echocardiography. c Quantitative analysis of EF and FS, ***p < 0.001. d Analysis of 18F-FDG cardiac uptake PET images with left ventricular polar maps (upper panels). Color on the map represents summed value of 18F-FDG uptake in the left ventricle. Cardiac 18F-FDG PET image was reoriented to the short-axis (SA), the horizontal long-axis (HLA), and the vertical long-axis (VLA). Quantification of 18F-FDG PET image in 20-segment polar map (bottom panels). Scores (%) of 18F-FDG uptake in the infarct area showed significant reduction in AAV-ETV2 group compared to that in the control group (n = 6, p < 0.05)

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