Fig. 7: CDK16 promotes cancer cell proliferation via PRC1 phosphorylation.

a Tumor cell lines were seeded and transfected the following day with siRNA targeting PRC1 and/or CDK16 or with scrambled control. Cell viability was assessed by an MTT assay, and the columns represent the means ± SEMs of at least 3 independent experiments performed in triplicate. *P < 0.05 vs control, Mann–Whitney test. b Tumor cell lines were seeded and transfected the following day with siRNA targeting PRC1 and/or CDK16 or with scrambled control. After 3 days, the cells were detached and seeded in 6-well plates. The colony formation ability was assessed 2 weeks later. The columns represent the means ± SEMs of at least 3 independent experiments performed in duplicate. *P < 0.05 vs control, Mann–Whitney test