Fig. 3: Acetate suppresses inflammasome-mediated peritoneal inflammation in vivo. | Experimental & Molecular Medicine

Fig. 3: Acetate suppresses inflammasome-mediated peritoneal inflammation in vivo.

From: Acetate attenuates inflammasome activation through GPR43-mediated Ca2+-dependent NLRP3 ubiquitination

Fig. 3

a–h Acetate (20 mM) suppressed MSU- (a–d) and alum-(e–g)-induced peritoneal inflammation. Flow cytometry revealed that neutrophils (CD11b+ GR-1+) (a, e), macrophages (F4/80+) (b, f), peritoneal exudate cells (PECs) (c, g) and IL-1β (ELISA) in the peritoneal lavage fluid (PLF) (d, h) were decreased in the acetate pretreatment group; i–l acetate suppressed LPS-induced peritonitis (n = 3). Serum levels of IL-6 (i), TNF-α (j), IL-1β (l), and IL-1β in PLF (k), as measured by ELISA, decreased in the acetate treatment group (n = 3); *P < 0.05, Student’s t-test compared with the model group (MSU, Alum or LPS). n = biological replicates. Data are presented as the mean ± SEM

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