Fig. 1: Autophagy pathway activation during Mtb infection.
From: Autophagy-activating strategies to promote innate defense against mycobacteria
After phagocytosis, Mtb can reside in phagosomes to escape phagosomal acidification. Numerous immunological and pharmacological autophagy activators (box on the left) can enhance the restriction of intracellular Mtb growth by overcoming Mtb escape from phagosomal maturation. Mtb phagosome damage through the ESX-1 system is able to trigger ubiquitination of Mtb and its DNA to recruit autophagic adaptors, thereby linking this system to the autophagic machinery. Although much less is known about LAP during Mtb infection, Mtb CpsA has been reported as an inhibitory component in resistance to LAP during infection. IFN interferon, LC3 Microtubule-associated proteins 1A/1B light chain 3B, NDP52 Nuclear domain 10 protein 52, TLR Toll-like receptor
