Fig. 6: The expression of genes promoting fibrosis is altered in the livers of rats treated with IPA, leading to a reduction in liver fibrosis. | Experimental & Molecular Medicine

Fig. 6: The expression of genes promoting fibrosis is altered in the livers of rats treated with IPA, leading to a reduction in liver fibrosis.

From: Indole-3-propionic acid inhibits gut dysbiosis and endotoxin leakage to attenuate steatohepatitis in rats

Fig. 6

a Representative Sirius Red and Masson trichrome staining of liver sections (scale bars, 50 μm). b Quantification of Sirius Red and Masson-stained areas is shown. c Fibrosis was scored based on histological alterations. The expression levels of fibrogenic genes (d) and collagen genes (e) were determined by real-time PCR. Relative expression levels were normalized to those of GAPDH. The data are presented as the mean ± SEM. n = 7–10, *P < 0.05, vs. rats fed a chow diet; #P < 0.05, vs. rats fed a high-fat diet

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