Table 1 Univariate and multivariate Cox regression analysis of disease-free survival in colorectal cancer (combined with CIT and AUS cohorts)

From: A prognostic index based on an eleven gene signature to predict systemic recurrences in colorectal cancer

Variable

Univariate

Multivariate

Multivariate (stepa)

n

HR (95% CI)

P-value

n

HR (95% CI)

P-value

n

HR (95% CI)

P-value

Gender (male vs. female)

782

0.803 (0.617–1.047)

0.105

721

0.78 (0.583–1.045)

0.096

721

0.783 (0.587–1.045)

0.097

Age (<75 or ≥75)

782

0.986 (0.736–1.321)

0.927

 

1.203 (0.858–1.685)

0.283

   

AJCC Stage (I, II, III, or IV)

782

2.837 (2.334–3.447)

<0.001

 

2.267 (1.781–2.885)

<0.001

 

2.327 (1.877–2.886)

<0.001

Location (distal, proximal, or rectum)

782

0.765 (0.602–0.973)

0.029

 

0.809 (0.622–1.053)

0.114

 

0.823 (0.636–1.066)

0.14

Chemotherapy (No or Yes)

766

1.841 (1.404–2.414)

<0.001

 

1.101 (0.789–1.536)

0.572

   

CMS subtype (CMS1, 2, 3, or 4)

736

1.274 (1.123–1.446)

<0.001

 

1.134 (0.992–1.296)

0.066

   

PI (low-risk or high-riskb)

782

1.984 (1.514–2.6)

<0.001

 

1.794 (1.327–2.426)

<0.001

 

1.812 (1.342–2.448)

<0.001

  1. HR hazard ratio, CI confidence interval, CMS consensus molecular subtype, PI prognostic index
  2. aA backward-forward step procedure was applied to optimize the multivariate model with the most informative variables
  3. bPredicted outcome in Fig. 2b, c was used for analysis
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