Fig. 4: Network analysis of proteins related to AD. | Experimental & Molecular Medicine

Fig. 4: Network analysis of proteins related to AD.

From: Deep proteome profiling of the hippocampus in the 5XFAD mouse model reveals biological process alterations and a novel biomarker of Alzheimer’s disease

Fig. 4

a The network model describing the protein-protein interactions (PPIs) of 92 AD-related proteins. Node colors represent an increase (red) or decrease (green) in 5-month-old 5XFAD mice (center) and 10-month-old 5XFAD mice (boundary) compared to age-matched wild-type mice. The color bar represents the gradient of log2 protein ratios. The size of a circle represents -log10(P) value, where P is the p-value. The edges represent PPIs obtained from the STRING database. b The AD-related proteins listed in Fig. 4a were examined by western blotting of hippocampal samples from 5- and 10-month-old wild-type and 5XFAD mice. c Quantification of the data shown in Fig. 4b (n = 3 per genotype for both ages; two-tailed unpaired t-test; **p < 0.01 and ***p < 0.001). The results are expressed as the mean ± SEM

Back to article page