Fig. 9: The mechanism by which lncRNA HOXA11-AS regulates stem cell characteristics in hepatocellular carcinoma via the modulation of HOXA11 gene expression and the Wnt signaling pathway. | Experimental & Molecular Medicine

Fig. 9: The mechanism by which lncRNA HOXA11-AS regulates stem cell characteristics in hepatocellular carcinoma via the modulation of HOXA11 gene expression and the Wnt signaling pathway.

From: Silencing of long noncoding RNA HOXA11-AS inhibits the Wnt signaling pathway via the upregulation of HOXA11 and thereby inhibits the proliferation, invasion, and self-renewal of hepatocellular carcinoma stem cells

Fig. 9

The lncRNA HOXA11-AS recruits DNMT1 to the promoter region of HOXA11, causing its methylation and subsequently resulting in suppression of HOXA11 expression and activation of the Wnt signaling pathway, which ultimately promotes stem cell characteristics in hepatocellular carcinoma

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