Fig. 7: Kidney organoids are transplantable into mouse kidneys with unilateral ureteral obstruction.
From: Graft immaturity and safety concerns in transplanted human kidney organoids
a Representative images of Trichrome staining, and immunohistochemical staining for α-SMA are shown. Cells were stained at 7 days after UUO. Scale bars, 100 μm. A zoom image shows few α-SMA positive cells in the grafts, whereas they were abundantly expressed in the neighboring mouse kidney tissue with UUO. Scale bar, 30 μm. b Representative images of H&E staining and immunohistochemical staining for safranin O. Arrows indicate cartilages and an arrow head indicate a cyst. Scale bars, 500 μm. c Representative images of immunohistochemical staining for HNA. Scale bars, 100 μm. Quantification of the length of cartilages (d) and cysts (e) (n = 3, 2 weeks vs. 4 weeks vs. 6 weeks after kidney organoids transplantation. *p < 0.05).
