Fig. 1: Classification of the CRISPR system and the operon organization for each subtype. | Experimental & Molecular Medicine

Fig. 1: Classification of the CRISPR system and the operon organization for each subtype.

From: Recent advances in the CRISPR genome editing tool set

Fig. 1

Genes belong to any step composed of the chromosomal integration of invaded DNA (adaptation), the production of CRISPR RNA (expression), and the cleavage of exogenous DNA (interference). The class 2 CRISPR system is characterized as a single nuclease effector protein, and type II, V, and VI constitute the Class 2 system. Types II and V show DNA cleavage activity, while type VI uses ssRNA as a substrate. A systematic name is given for all effector nucleases with a legacy name in parentheses for several nucleases. The dashed arrows indicate that cas1 and cas2 genes are present in only some bacterial or archeal chromosomes. The X mark denoted in Cas12k refers to a catalytically inactive RuvC-like domain

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