Table 1 Comparison of pathological phenotype similarity between human psoriasis and Peli1 expressing mice.

From: Pellino1 promotes chronic inflammatory skin disease via keratinocyte hyperproliferation and induction of the T helper 17 response

 

Human psoriasis

Phenotype in Peli1 expressing mice

Epidermal changes

Thickening

Y

Y

Altered differentiation

Y

Y

Rete ridges

Y

Y

Papillomatosis

N

N

Vascular changes

Dilation of capillary loops

Y

Y

Inflammatory changes

Epidermal T cell infilteration

Y

Y

Intra-epidermal microabscesses

Y

Y

others

“Koebner” phenomenon

Y

nd

Phenotype dependent on immune activation

Y

Y

Features unlike human psoriasis

 

Retarded growth, hair abnormality

  1. Y yes, N no, nd not yet determined.
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