Fig. 3: CRLs and cell cycle progression through G2/M.
From: Regulation of cell cycle drivers by Cullin-RING ubiquitin ligases
a Diagram depicting how CRLs promote timely substrate ubiquitination during G2/M. Substrates are categorized into five groups (transcription, CDK activities, chromosomes, modulators of other E3 ligases and others) and color coded to match their CRLs. b Schematic summary of CRLs, substrate receptors and substrates involved in the regulation of cell cycle progression through G2/M. Substrates are categorized into three groups (regulation of transcription, regulation of CDKs and mitotic factors and regulation of other E3 ligases). CRL complexes, substrate receptors, phosphorylation and ubiquitination are color coded as indicated.
