Fig. 5: FOXO1 downregulation reversed high glucose-mediated endothelial inflammation. | Experimental & Molecular Medicine

Fig. 5: FOXO1 downregulation reversed high glucose-mediated endothelial inflammation.

From: SET8 suppression mediates high glucose-induced vascular endothelial inflammation via the upregulation of PTEN

Fig. 5

a Results from the western blot analysis of PTEN, p-p65, e-selectin, and ICAM-1 expressions in HUVECs expressing siFOXO1 under high-glucose conditions. b Results from the qPCR analysis of PTEN, p-p65, e-selectin, and ICAM-1 expressions in HUVECs expressing siFOXO1 under high-glucose conditions. c The effects of siFOXO1 on high glucose-induced monocyte/endothelial adhesion were measured. d Results from the western blot analysis of PTEN, p-p65, e-selectin, and ICAM-1 expressions in HUVECs with siPTEN under FOXO1 overexpression conditions. e Results from the qPCR analysis of PTEN, p-p65, e-selectin, and ICAM-1 expressions in HUVECs with siPTEN and overexpressing FOXO1. f The effects of siPTEN on FOXO1 overexpression-induced monocyte/endothelial adhesion were measured. *P < 0.05, compared with the control group; #P < 0.05, compared with the high-glucose treatment group, n = 5/group.

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