Fig. 6: METTL3 promotes BC cell resistance to ADR by enhancing miR-221-3p expression in vivo. | Experimental & Molecular Medicine

Fig. 6: METTL3 promotes BC cell resistance to ADR by enhancing miR-221-3p expression in vivo.

From: METTL3 promotes adriamycin resistance in MCF-7 breast cancer cells by accelerating pri-microRNA-221-3p maturation in a m6A-dependent manner

Fig. 6

a The expression of miR-221-3p in mouse tumor tissues. b Immunoblots and quantification of HIPK2 and Che-1 in mouse tumor tissues, normalized to GAPDH. c Representative images of BC xenografts in nude mice. d The growth curve of BC xenografts in nude mice. e The weight of BC xenografts in nude mice. *p < 0.05 compared to oe-NC + NC inhibitor + ADR and #p < 0.05 compared to oe-NC + miR-221-3p inhibitor + ADR by Tukey’s test-corrected ANOVA or by Bonferroni-corrected repeated measures ANOVA for d.

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