Fig. 4: Effects of oral NUC on the abundance of gut microbiota in HFD-fed rats.

Bacterial taxonomic profiling at the genus level of intestinal bacteria from different groups (a) is shown. The relative abundances of Desulfovibrio (b), Lachnospiraceae_NK4A136_group (c), Prevotella_9 (d), Bacteroides (e), Anaerotruncus (f), Christensenellaceae_R-7_group (g), Allobaculum (h), Ruminococcaceae_UCG-009 (i), and Enterorhabdus (j) are shown. Linear discriminant analysis (LDA) scores (k) and the cladogram (l) were generated from linear discriminate analysis effect size (LEfSe) analysis, showing the biomarker taxa (LDA score of >2 and a significance of P < 0.05 determined by the Wilcoxon signed-rank test). In (l), the species with no significant difference were uniformly colored yellow, and the red node and green node represent the bacteria that played an important role in the red group and green group, respectively. Values are presented as the mean±SD (n = 5 per group). ^#P < 0.05, ^##P < 0.01, ^###P < 0.001 vs ND, *P < 0.05, **P < 0.01, ^***P < 0.001 vs HFD.