Fig. 5: The M2 phenotype of TAMs can be applied to predict the prognosis in gastric cancer.

a Transcriptome-driven M2 signatures, not curated signatures, are high exclusively in M2-type cells. M1 reference M1 cells, M2 reference M2 cells, TAM macrophages from GC, Epi epithelial cells from GC, Meso mesothelial cells from GC. b Overall survival prediction was performed using the TCGA STAD dataset (n = 378) and either signature gene sets or canonical macrophage markers, such as CD68 and CD163. The ‘high’ group (red) and ‘low’ group (blue) were determined by the 25th and 75th percentiles, respectively. p indicates the p-value of log-rank test. c Summary table of p-values for overall survival using the TCGA dataset for the three cancer types (STAD, n = 378; COAD, n = 270; and BRCA, n = 1059).