Table 3 Metabolic profile analysis of mouse parameters.

From: Long noncoding RNA NEAT1 is involved in the protective effect of Klotho on renal tubular epithelial cells in diabetic kidney disease through the ERK1/2 signaling pathway

Parameter

Sham

STZ + HFD

DM + pCMV-Vector

DM + pCMV-Klotho

Glucose (mM)

8.85 ± 0.40

20.95 ± 0.85**

18.65 ± 3.40

20.15 ± 4.02

Urine microalbumin (µg/24 h)

8.17 ± 0.92

88.29 ± 8.67**

80.23 ± 8.46

60.25 ± 6.65#

Renal weight index (mg/kg)

6.68 ± 0.62

13.73 ± 2.95*

12.33 ± 2.67

13.18 ± 2.49

Body weight (g)

27.31 ± 1.97

23.30 ± 3.47

24.13 ± 2.13

23.81 ± 3.24

CH (mM)

4.07 ± 1.02

6.84 ± 0.97*

6.46 ± 1.03

6.76 ± 0.98

TG (mM)

5.17 ± 0.55

7.55 ± 0.22**

7.06 ± 0.47

6.97 ± 0.62

LDL-C (mM)

2.39 ± 0.41

4.26 ± 0.35**

4.42 ± 0.38

4.06 ± 0.42

Serum Klotho (pg/ml)

12.91 ± 1.17

6.66 ± 0.301**

6.56 ± 1.01

8.86 ± 2.31#

  1. Mean ± SEM; n = 5; *P < 0.05 and **P < 0.01 versus Sham; #P < 0.05 versus DM + pCMV-Vector.
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