Fig. 3: Bioengineered platforms for developing GI organoids assembled with other types of organoids.
From: Gastrointestinal tract modeling using organoids engineered with cellular and microbiota niches
Through bioengineering techniques such as 3D bioprinting and the use of microfluidics and biomaterials, a novel integrated GI system can be developed by connecting the various organoids that make up the digestive system or by coculturing with completely different types of organoids such as brain organoids. These innovative organoid systems enable the modeling of highly complex human physiology, such as reciprocal regulation between the GI tract and other major organs, and pathological phenomena associated with diseases.
